Research on the effects of honey on our immune system

Honey

Honey

Crystallized honey is ideal as an absorption booster.

Honey should be kept in the oral cavity, preferably under the tongue, for as long as possible until the crystals dissolve gently. The substances dissolved in honey reach the bloodstream directly through the mucous membrane.

Honey is the best preservative

Pre-Christian cultures used honey to preserve valuable food for eternity. For years they preserved fresh fruit, vegetables, fish, meat and valuable seeds in raw honey. Real properly stored honey never goes bad. More than 3000 years old honey from Egyptian graves is still edible. During their lavish celebrations, the Romans enjoyed fruits and other foods from distant areas, which were transported in honey and thus remained fresh.[1]

Honey in traditional healing practices

People have been using the healing properties of honey since the Stone Age.[2]

The outstanding effect of honey on our body is well known in all traditional healing practices. Because of bаktеrіzіdes and bacteriostatic [3] properties, it has been and is used externally and internally to treat a variety of diseases, injuries and ailments.

India 
Ayurveda recommends honey for the treatment of poor digestion, irritating cough, asthma, bronchial tuberculosis, insomnia, heart pain, palpitations, lung imbalance, hepatitis, worm infestation, constipation, anemia, eye diseases (such as cataracts) and to keep teeth and gums healthy, treatment vomiting, diarrhea, rheumatoid arthritis, obesity, diabetes mellitus and for the preservation of meat and fruits.[4]

Egypt
honey was the most popular Egyptian remedy. It was mentioned 500 times in 900 recipes.[5] They also used honey to embalm the dead.

Greece
Honey is used in Greece as an
oenomel remedy traditionally as a folk remedy and nervous disorders. Hippocrates prescribed as Oxymel (vinegar and honey) for pain, honey and medicinal plants for acute fever,[6] he used honey for baldness, contraception, wound healing, laxatives, coughs and sore throats, eye diseases, topical antisepsis, prevention and treatment of scars[7]

Islamic medicine
Prophet Mohammad recommended honey To Treat Diarrhea [8] Avicenna hadhoney as one of the best drugs to treat tuberculosis [9] recommended.

Traditional Chinese Medicine
In Traditional Chinese Medicine (TCM), honey was used as an additive in herbal medicines to improve their immunostimulatory activities.[10]

Due to the antibiotics, the effects of honey have been forgotten. Only with the appearance of multi-resistant microorganisms is medicine forced to respect the antibiotic effect of honey.

Researches:

Honey for Respiratory

Honey has good antibacterial, antifungal, and antiviral properties, and Infectionsis superior to prescription drugs, and antibiotics for relieving symptoms of upper respiratory infections[11]. No honey-resistantyet phenotypes have appeared.[12] [13] Honey does not and can cause the development of antibiotic-resistant bacteria Continuous use[14]

Honey for gastrointestinal disorders

Honey istreating colitis just as effective as prednisolone in[15]. Oral administration provides protection against gastrointestinal infections such as gastritis, duodenitis and gastric ulcers caused by bacteria and rotaviruses.[16] [17] [18] [19] Blocks the deposition of pathogenic microorganisms on the intestinal epithelium and protects against bacterial infection of the gastrointestinal tract [20]. Honey quickly resolves diarrhea and gastroenteritis[21] [22]. It can be used to heal stomach ulcersulcers, and [23] as well as vomiting, diarrhea, rheumatoid arthritis, and obesity [24] .

Honey and Diabetes

Honey lowers blood lipids, homocysteine ??levels, and C-reactive protein levels [25]. Honey stimulates insulin secretion, lowers blood sugar levels, increases hemoglobin concentration and improves lipid profile[26] [27]

Honey and cardiovascular diseases

Honey lowers cardiovascular risk factors such as the formation of free radicals and hyperlipidemia [28] [29] Honey lowers venous blood pressure, which reduces tension in the heart and clogging in the venous system [30]. Consumption of natural honey for five weeks has strong anti-arrhythmic and infarct-inhibiting effects [31].


[1] Dr. S. Mladenov, The Preservative Effect of Honey, Pchelarstvo Magazine, issue 12, 1967
[Honeypedia]

[2] Bansal V, Medhi B, Pandhi P. Honey a remedy rediscovered and its therapeutic utility. Kathmandu Univ Med J (KUMJ). 2005 Jul-Sep; 3 (3): 305-9. PMID: 18650599.
[PubMed]

[3] bactericidal = germicidal, bacteriostatic = inhibiting the growth or reproduction of bacteria

[4] Ediriweera E., Premarathna N. Medicinal and cosmetic uses of bee's honey - A review. Ayu. 2012; 33: 178.
[PMC free article]

[5]  Al-Jabri AA. Honey, milk and antibiotics. Afr J Biotechnol. 2005; 4: 1580-1587.
[AJB]

[6] Honey - a remedy rediscovered. Zumla A, Lulat AJR Soc Med. 1989 Jul; 82 (7): 384-5.
[PubMed]

[7]  Bansal V, Medhi B, Pandhi P. Honey a remedy rediscovered and its therapeutic utility. Kathmandu Univ Med J (KUMJ). 2005 Jul-Sep; 3 (3): 305-9. PMID: 18650599.
[PubMed]

[8] Molan PC. Why honey is effective as a medicine. 1. Its use in modern medicine. Bee World. 1999; 80: 80-92.
[TaylorFrancis]

[9] The antimycobacterial effect of honey: an in vitro study. Asadi-Pooya AA, Pnjehshahin MR, Beheshti S Riv Biol. 2003 Sep-Dec; 96 (3): 491-5.
[PubMed]

[10] The immunostimulatory effects and chemical characteristics of heated honey. Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-Dori, Mizuho-ku, Nagoya 467-8603, Japan
[PubMed]

[11] Abuelgasim H, Albury C, Lee J. Effectiveness of honey for symptomatic relief in upper respiratory tract infections: a systematic review and meta-analysis. BMJ Evid Based Med. 2020 Aug 18: bmjebm-2020-111336. doi: 10.1136 / bmjebm-2020-111336. Epub ahead of print. PMID: 32817011.
[PubMed]

[12] Maddocks SE, Jenkins RE. Honey: a sweet solution to the growing problem of antimicrobial resistance? Future Microbiol. 2013 Nov; 8 (11): 1419-29. doi: 10.2217 / fmb.13.105. PMID: 24199801.
[FutureMedicine]

[13] Bacteria can't resist honey. Dixon B Lancet Infect Dis. 2003 Feb; 3 (2): 116.
[PubMed

[14] A different and safe method of split thickness skin graft fixation: medical honey application. Emsen IM Burns. 2007 Sep; 33 (6): 782-7.
[PubMed]

[15] Bilsel Y, Bugra D, Yamaner S, Bulut T, Cevikbas U, Turkoglu U. Could honey have a place in colitis therapy? Effects of honey, prednisolone and disulfiram on inflammation, nitric oxide, and free radical formation. Dig Surg. 2002; 19: 306-311.
[PubMed]

[16] Tallet S, Mackkenzie C, Middleton P, Kerzner B, Hamilton R. Clinical, laboratory and epidemiologic features of viral gastroenteritis in infants and children. Pediatrics. 1977; 60: 217-222.
[PubMed]

[17] Haffejee I, Moosa AE. Honey in the treatment of infantile gastroenteritis. Br Med J. 1985; 290: 1866-1867.
[PMC free article]

[18] Somal N, Coley K, Molan P, Hancock B. Susceptibility of Helicobacter pylori to the antibacterial activity of Manuka honey. J Royal Soc Med. 1994; 87: 9-12.
[PMC free article]

[19] Topham J. Why do some cavity wounds treated with honey or sugar paste heal without scarring? J Wound Care. 2002; 11: 53-55.
[PubMed]

[20] Alnaqdy A, Al-Jabri A, Al Mahrooqi Z, Nzeako B, Nsanze H. Inhibition effect of honey on the adherence of Salmonella to intestinal epithelial cells in vitro. Int J Food Microbiol. 2005; 103: 347-351.
[PubMed]

[21] Honey-a remedy rediscovered and its therapeutic utility. Bansal V, Medhi B, Pandhi P Kathmandu Univ Med J (KUMJ). 2005 Jul-Sep; 3 (3): 305-9.
[PubMed]

[22] The antibacterial effect of honey on diarrhea causing bacterial agents isolated in Lagos, Nigeria. Obi CL, Ugoji EO, Edun SA, Lawal SF, Anyiwo CE Afr J Med Med Sci. 1994 Sep; 23 (3): 257-60.
[PubMed]

[23] Ali ATM. Natural honey accelerates healing of indomethacin-induced antral ulcers in rats. Saudi Med J. 1995; 16: 161-166.
[WHO]

[24] Ediriweera ER, Premarathna NY. Medicinal and cosmetic uses of Bee's Honey - A review. Ayu. 2012; 33 (2): 178-182. doi: 10.4103 / 0974-8520.105233
[PMC] 

[25] Natural honey lowers plasma glucose, C-reactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects: comparison with dextrose and sucrose. Al-Waili NS J Med Food. 2004 Spring; 7 (1): 100-7.
[PubMed]

[26] Effect of honey on antibody production against thymus-dependent and thymus-independent antigens in primary and secondary immune responses. Al-Waili NS, Haq AJ Med Food. 2004 winter; 7 (4): 491-4.
[PubMed]

[27]  Bahrami M, Ataie-Jafari A, Hosseini S, Forouzanfar M, Rahmani M, Pajouhi M. Effects of natural honey consumption in diabetic patients: an 8-week randomized clinical trial. Int J Food Sci Nutr. 2008; 2: 1-9.
[PubMed]

[28]  Schramm DD, Karim M, Schrader HR, Holt RR, Cardetti M, Keen CL. Honey with high levels of antioxidants can provide protection to healthy human subjects. J Agric Food Chem. 2003; 51: 1732-1735.
[PubMed]

[29] Yaghoobi N, Al-Waili N, Ghayour-Mobarhan M, Parizadeh SMR, Abasalti Z, Yaghoobi Z, et al. Natural honey and cardiovascular risk factors; effects on blood glucose, cholesterol, triacylglycerols, CRP and body weight compared with sucrose. Sci World J. 2008; 8: 463-469.
[PMC free article]

[30] Rakha MK, Nabil ZI, Hussein AA. Cardioactive and vasoactive effects of natural wild honey against cardiac malperformance induced by hyperadrenergic activity. J Med Food. 2008; 11: 91-98.
[PubMed]

[31]  Najafi M, Shaseb E, Ghaffary S, Fakhrju A, Eteraf-Oskouei T. Effects of chronic oral administration of natural honey on ischemia / reperfusion-induced arrhythmias in isolated rat heart. Iran J Basic Med Sci. 2011; 14: 75-81.
[eprints]