Forschungen über wirkung von Aronia auf unsere immunsystem

Aronia

Aronia (Aronia melanocarpa)

in der russischen Volksheilkunde seit Jahrzehnten bewährt

Die Aroniabeere oder Apfelbeere stammt ursprünglich aus Nordamerika wo sie vom Indianerstamm der Potawatomi zur Heilung von Erkältungen eingesetzt wurde.[1] Anfang des 20. Jahrhunderts kam die Pflanze in die Sowjetunion und nach Europa. Besonders in Russland und Osteuropa wird sie seit Jahrzehnten in der Schulmedizin und Volksheilkunde als Heilpflanze verwendet, bei Infektions- und Kinderkrankheiten wie Masern oder Scharlach, Bluthochdruckerkrankungen, Behandlung  von  Magen-,  Darm-,  Drüsen-  sowie  Leber-  Gallenblasenerkrankungen Magenentzündungen  und Vitaminmangelerkrankungen, Strahlenkrankheiten, Vergiftungen durch Schwermetalle und bei somatischen Strahlenschäden eingesetzt [2]

Forschungen bestätigen die Vielseitigkeit Aroniabeere

Aronia kann Schwermetalle ausleiten und schützt vor radioaktiven Strahlen, hat antioxidative, entzündungshemmende, antivirale, krebsbekämpfende, antiatherosklerotische, blutdrucksenkende, blutplättchenhemmende und antidiabetische sowie blutgefäßschützende Eigenschaften.[3]

Antioxidative Eigenschaften:

Apfelbeeren haben starke antioxidative [4] Eigenschaften und sind die stärksten Radikalfänger von allen Beeren. [5] [6] Deswegen können sie wirksam bei Prophylaxe und Behandlung von mit oxidativem Stress verbundenen Gesundheitsstörungen, insbesondere Strahlenkrankheit,[7] [7a] Krebs [8] und Diabetes [9] eingesetzt werden.

Entzündungshemmend:

Wegen der starken entzündungshemmenden Eigenschaften können Aronia-Beeren Produkte vor mit entzündlichen Prozessen verbundenen pathologischen Zuständen wie bei Diabetes [10] Herz - Kreislauf - Erkrankungen [11] Hautkrankheiten [12] Augenkrankheiten [13] Immunsystemstörungen [14]  [15] schützen.

Entgiftung

Aronia kannToxine ausleiten und Gesundheitsschäden hemmen.
Cadmium-Hemmung bei Schädigung der Nieren[16] [17] , Lebergewebe [18] ,Knochen[19] [20]. Mindert Cadmium-Lagerung im Hirn[21] ,Blut, Leber, Nieren, Knochen[22], osteoprotektive Wirkung[23] 

Blei - Verringert die Konzentration in den inneren Organen, im Knochengewebe und Urin, bietet vollständigen Schutz der Leber vor histologischen Veränderungen[24] [25] [26]. Alkoholkonsum - Schutz des Magens, der Leber und der Nerven [27] [28] [29], Hemmung von Magengeschwüren und die Lipidperoxidation in Lunge, Leber und Dünndarm [30], mindert Angstzuständen und Depressionen [31].

Nitrosoverbindungen - (Tabakrauch, geräuchertes Fleisch, Milchpulver Düngemittel, Kinderspielzeug aus Natur-und Synthesekautschuk). Aronia verhindert die Produktion von krebserregende Nitrosoverbindungen [32] [33] 

Herbizide - die in der Apfelbeere vorhandenen Polyphenol-Verbindungen wie Chlorogensäure, Quercetin und Kaempferol bieten einen Schutz von Paraquat [34] [35]  Senfgas und seine Derivate (chemo) - orale und topische Verabreichung von in Apfelbeeren vorhandenen Anthocyanen und Quercetin hemmt den Schaden bei roten Blutkörperchen, Lunge, Dünndarm, Leber, Milz und Haut [36] [37] 7,12-Dimethylbenzo (a) anthracen [38], Entgiftung in der Leber[39] 

Methamphetamine (Crystal Meth) - Chlorogene und Kaftarsäuren können vor Leberschaden und die Erythrozyten vor oxidativem Stress schützen.[40] 

Tabakrauch - Apfelbeere-Extrakt hemmt eine durch Tabakrauch verursachte Leberdegeneration, krankhafte Gewebeveränderungen in der Lunge, Entwicklung von Lungentumoren[41], Erythrozyten, Knochenmark sowie den Gewichtsverlust [42] [43] [44], Erzeugung und Freisetzung von Superoxid Radikalen [45] und einen Schaden auf Osteoblasten indem es die Radikale abfängt, die Knochenmasse, die Stabilität und die Frakturheilung verbessert.[46]

Aronia kann viele Nebenwirkungen von Arzneien lindern

Amiodaron [47] - Pneumotoxizität [48], Indomethacin [49] - Magenschleimhaut Schäden [50], Cisplatin [51] - Zytotoxizität Nierenzelle [52], Cyclophosphamid [53] und Ziprasidon [54] - Abnahme der Aktivitäten antioxidativer Enzyme in gesunden Zellen[55] [56],  Paracetamol [57]- hepatorenaler Toxizität in Leber- und Nierengewebe [58],  Rifampicin [59] und Isoniazid [60]- Leberschäden [61],  Etoposid [62]- apoptose HL-60-Zellen [63]

Krankheitsvorbeugung

Aroniabeeren sind reich an Polyphenolen, die zu den wichtigsten Antioxidantien zählen und den Körper vor freien Radikalen und damit vor verschiedenen Erkrankungen schützen.
Diabetes- reguliert den Blutzuckerspiegel [64] [65] die Wirksamkeit von Insulin wird erhöht [66] und das Diabetes-Risiko gesenkt [67] [68]
Herz-Kreislauf-Erkrankungen - Aronia hemmt die Blutgerinnung [69] [70] [71], normalisiert den  Blutdruck [72] [73] [74], schützt die Arterien [75] [76] [77] und Herzmuskel [78],  schützt vor metabolischem Syndrom (Übergewicht, Bluthochdruck und gestörter Fettstoffwechsel) und hemmt den Fortschritt dieses Zustandsbildes [79] [80] [81].

Krebs -  Aronia Produkte hindern die Krebsentwicklung: Nach zweitägiger Verabreichung von Apfelbeeren-Extrakt wurde das Tumorzellen-Wachstum um 50% gehemmt [82]. Aronia Produkte schützen gesunde Zellen vor freien Radikalen, erhöhen die Wirksamkeit von Krebsmedikamenten [83], akkumulieren Cyanidin-Glycoside in Tumorzellen und gewähren den Tod von Zellen mit krebserzeugenden Veränderungen. [84]  Der Verzehr von Apfelbeer-Produkten schützt vor Nebenwirkungen von Arzneimitteln die in der Chemotherapie verwendet werden. Die Verabreichung von Apfelbeere-Extrakt reguliert den Gehalt an niedermolekularen Thiolen im Plasma bei mit Chemotherapie behandelten Krebspatienten auf den Wert von gesunden Probanden [85]. Eine Positive Wirkung von Aronia wurde bei Pankreas-[86], Dickdarm- [87] [88] [89] [90], Brust- [91] [92] [93], Lungen- [94] und Gebärmutterhalskrebs [95], Hirntumor - Glioblastom [96] (Aronia- Extrakt bewirkt eine Herabregulierung von Matrixmetalloproteinasen MMP-2, MMP-12, MMP-16, MMP-17 in der U 373-Glioblastomzellen)[97], Leukämie (auch bei Chemotherapie resistenten Leukämie) [98] [99] nachgewiesen. 

Verdauungssystem Störungen 

Aronia bietet Schutz vor Verdauungsstörungen wie Fettlebererkrankung [100] [101] [102] Zirrhose [103] Magengeschwüren [104].

Andere Gesundheitsprobleme

Aronia-Produkte können Cellulite,  Ödeme [105] Fettleibigkeit und Übergewicht verhindern [106], [107] bei männlicher Unfruchtbarkeit [108] [109], Prostatavergrösserung [110], Depressionen [111], Angst [112] und komplizierten Schwangerschaften [113] helfen.

Kinder unter 3 Jahren sollten Aroniabeeren nicht essen. Auch für Menschen, die Probleme mit der Blutgerinnung haben oder an Gastritis leiden, sind sie nicht empfehlenswert. Wegen der blutdrucksenkenden Wirkung der Beeren sollten auch Menschen mit niedrigem Blutdruck vorsichtig sein.[114]  Die Rücksprache mit einem Arzt wird empfohlen.


[1] Überblick über die traditionelle Verwendung von Aroniapflanzen: Kokotkiewicz A, Jaremicz Z, Luczkiewicz M. Aronia plants: a review of traditional use, biological activities, and perspectives for modern medicine. J Med Food. 2010;13(2):255-269.
[
PubMed]

[2] Gesundheitsfördernde Inhaltsstoffe der Aronia melanocarpa: Christine Misfeldt, Gesundheitsfördernde Inhaltsstoffe der Aronia melanocarpa, 2007
[
HAW Hamburg]

[3] Borowska, S. and Brzóska, M.M. (2016), Chokeberries (Aronia melanocarpa) and Their Products as a Possible Means for the Prevention and Treatment of Noncommunicable Diseases and Unfavorable Health Effects Due to Exposure to Xenobiotics. COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, 15: 982-1017.
[Wiley Online Library]

[4] Graversen HB, Becker EM, Skibsted LH, Andersen ML. 2008. Antioxidant synergism between fruit juice and a-tocopherol. A comparison between high-phenolic black chokeberry (Aronia melanocarpa) and high-ascorbic blackcurrant (Ribes nigrum). Eur Food Res Technol 226:737–43.
Web of Science®

[5] Jakobek L, Šeruga M, Medvidovic-Kosanovic M, Novak I. 2007. Antioxidant activity and polyphenols of Aronia in comparison to other berry species. Agric Conspec Sci 72:301–6.
Hrcak

[6] Bräunlich M, Slimestad R, Wangensteen H, Brede C, Malterud KE, Barsett H. 2013c. Extracts, anthocyanins and procyanidins from Aronia melanocarpa as radical scavengers and enzyme inhibitors. Nutrients 5:663–78.
PubMed

[7] Andryskowski G, Niedworok J, Maziarz Z, Malkowski B. 1998a. Protective effect of natural anthocyanin dye on experimental radiation sickness. Acta Pol Toxicol 6:155–62.
CEON

[7a] Reza Ghasemnezhad Targhi, Mansour Homayoun, Somaieh Mansouri, Mohammad Soukhtanloo, Shokouhozaman Soleymanifard, Masoumeh Seghatoleslam, Radio protective effect of black mulberry extract on radiation-induced damage in bone marrow cells and liver in the rat, Radiation Physics and Chemistry,Volume 130,2017,
sciencedirect

[8] Olas B, Kedzierska M, Wachowicz B, Stochmal A, Oleszek W, Jeziorski A. 2010. Effect of aronia on thiol levels in plasma of breast cancer patients. Cent Eur J Biol 5:38–46.
Web of Science®

[9] Rugina D, Diaconeasa Z, Coman C, Bunea A, Socaciu C, Pintea A. 2015. Chokeberry anthocyanin extract as pancreatic ß-cell protectors in two models of induced oxidative stress. Oxid Med Cell Longev 2015:429075.
PubMed

[10] Broncel M, Koziróg M, Duchnowicz P, Koter-Michalak M, Sikora J, Chojnowska-Jezierska J. 2010. Aronia melanocarpa extract reduces blood pressure, serum endothelin, lipid, and oxidative stress marker levels in patients with metabolic syndrome. Med Sci Monitor 16:CR28–34.
PubMed

[11] Zapolska-Downar D, Bryk D, Malecki M, Hajdukiewicz K, Sitkiewicz D. 2012. Aronia melanocarpa fruit extract exhibits anti-inflammatory activity in human aortic endothelial cells. Eur J Nutr 51:563–72.
PubMed

[12] Young KN, Young LH. 2015. Skin anti-inflammatory activity of nano-encapsulated Aronia melanocarpa extracts. Res J Biotechnol 10:62–74.
Web of Science®

[13] Ohgami K, Ilieva I, Shiratori K, Koyama Y, Jin XH, Yoshida K, Kase S, Kitaichi N, Suzuki Y, Tanaka T, Ohno S. 2005. Anti-inflammatory efects of Aronia extract on rat endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 46:275–81.
PubMed

[14] Ho GTT, Bräunlich M, Austarheim I, Wangensteen H, Malterud KE, Slimestad R, Barsett H. 2014. Immunomodulating activity of Aronia melanocarpa polyphenols. Int J Mol Sci 15:11626–36.
PubMed

[15] Appel K, Meiser P, Millán E, Collado JA, Rose T, Gras CC, Carle R, Muñoz E. 2015. Chokeberry (Aronia melanocarpa (Michx.) Elliot) concentrate inhibits NF-?B and synergizes with selenium to inhibit the release of pro-inflammatory mediators in macrophages. Fitoterapia 105:73–82.
PubMed

[16] Prabu SM, Shagirtha K, Renugadevi J. 2011. Quercetin in combination with vitamins (C and E) improve oxidative stress and hepatic injury in cadmium intoxicated rats. Biomed Prev Nutr 1:1–7.
[PubMed]

[17] Wang L, Lin SQ, He YL, Liu G, Wang ZY. 2013. Protective effects of quercetin on cadmium-induced cytotoxicity in primary cultures of rat proximal tubular cells. Biomed Environ Sci 26:258–67.
PubMed

[18] Krishnakumar N, Prabu SM, Sulfikkarali NK. 2012. Quercetin protects against cadmium-induced biochemical and structural changes in rat liver revealed by FT-IR spectroscopy. Biomed Prev Nutr 2:179–85.
[Science Direct]

[19] Brzóska MM, Roszczenko A, Rogalska J. 2013. Protective effect of polyphenols from Aronia melanocarpa berries against cadmium-induced weakening of the femur biomechanical properties in rats. Bone Abstracts. European Calcified Tissue Society Congress; Lisbon, Portugal 18–21 May 2013.
[
Bone Abstracts]

[20] Roszczenko A, Brzóska MM, Rogalska J. 2013. Beneficial impact of polyphenolic compounds from Aronia melanocarpa berries on the biomechanical properties of the lumbar spine vertebral body in cadmium exposed rats. Toxicol Lett 221S:S249.
Web of Science®

[21] Hao ML, Pan N, Zhang QH, Wang XH. 2015. Therapeutic efficacy of chlorogenic acid on cadmium-induced oxidative neuropathy in a murine model. Exp Ther Med 9:1887–94.
PubMed

[22] Brzóska MM, Galazyn-Sidorczuk M, Jurczuk M, Tomczyk M. 2015a. Protective effect of Aronia melanocarpa polyphenols on cadmium accumulation in the body: a study in a rat model of human exposure to this metal. Curr Drug Targets 16:1470–87.
PubMed

[23] Brzóska MM, Rogalska J, Roszczenko A, Galazyn-Sidorczuk A, Tomczyk M. 2016b. The mechanism of the osteoprotective action of a polyphenol-rich Aronia melanocarpa extract during chronic exposure to cadmium is mediated by the oxidative defence system. Planta Med 82:621–31.
PubMed

[24] Kowalczyk E , Jankowski A , Niedworok J , Smigielski J , Jankowska B . 2002 . [Die Wirkung von Anthocyanen von Aronia Aronia und Acetylcystein auf ausgewählte Nachwirkung Bleiacetat Vergiftungs] . Pol Merkur Lek 12 : 221 - 3 .
PubMed

[25] Kowalczyk E, Jankowski A, Niedworok J, Smigielski J, Jankowska B. 2003a. [The influence of Aronia melanocarpa Elliot and acetylcysteine on selected biochemical parameters of experimental animals with chronic lead acetate poisoning]. Folia Med Cracov 44:207–14.
PubMed

[26]Liu CM, Zheng YL, Lu J, Zhang ZF, Fan SH, Wu DM, Ma JQ. 2010a. Quercetin protects rat liver against lead-induced oxidative stress and apoptosis. Environ Toxicol Pharmacol 29:158–66.
PubMed

[27] Molina MF , Sanchez-Reus I , Iglesias I , Benedi J . 2003 . Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver.Biol Pharm Bull 26 : 1398 - 402. PubMed

[28] Matsumoto M, Hara, H, Chiji H, Kasai T. 2004. Gastroprotective effect of red pigments in black chokeberry fruit (Aronia melanocarpa Elliot) on acute gastric hemorrhagic lesions in rats. J Agric Food Chem 52:2226–9.
PubMed

[29] Liu S, Hou W, Yao P, Zhang B, Sun S, Nüsler AK, Liu L. 2010b. Quercetin protects against ethanol-induced oxidative damage in rat primary hepatocytes. Toxicol in Vitro 24:516–22.
PubMed

[30] Niedworok J, Jankowska B, Kowalczyk E, Charyk K, Kubat Z. 1997. [Antiulcer activity of anthocyanin from Aronia melanocarpa Elliot].
Herba Pol 43:222–7. 

[31] Valcheva-Kuzmanova S , Eftimov M , Denev P , Krachanova M , Belcheva A . 2013b Effect of aronia melanocarpa fruit juice on alcohol-induced depressive-like behavior in rats.
Scr Sci Med

[32] Atanasova-Goranova VK, Dimova PI, Pevicharova GT. 1997. Effect of food products on endogenous generation of N-nitrosamines in rats. Br J Nutr 78:335–45
PubMed

[33] Hernández-Ramírez RU, Galván-Portillo MV, Ward MH, Agudo A, González CA, Onate-Ocana LF, Herrera-Goepfert R, Palma-Coca O, López-Corrillo O. 2009. Dietary intake of polyphenols, nitrate and nitrite and gastric cancer risk in Mexico City. Int J Cancer 125:1424–30.
PubMed

[34] Tsuchiya T, Suzuki O, Igarashi K. 1996. Protective effects of chlorogenic acid on paraquat-induced oxidative stress in rats. Biosci Biotech Biochem 60:765–8.
PubMed

[35] Podder B, Song KS, Song HY, Kim YS. 2014. Cytoprotective effect of kaempferol on paraquat-exposed BEAS-2B cells via modulating expression of MUC5AC. Biol Pharm Bull 37:1486–94.
PubMed

[36] Kowalczyk E, Charyk K, Fijalkowski P, Niedworok J, Blaszczyk J, Kowalski J. 2004. Protective influence of natural anthocyanins of Aronia melanocarpa on selected parameters of antioxidative status in experimental intoxication with sulphide-2-chloroethyl-3-chloropropyl. Pol J Environ Stud 13:339–41.
Web of Science

[37] Gautam A, Vijayaraghavan R, Pant SC, Kumar O, Singh S, Kumar HTS. 2007. Protective effect of quercetin against sulphur mustard-induced oxidative stress in mice. Defence Sci J 57:707–20.
Web of Science

[38] (DMBA) einer der stärksten krebserregenden polyzyklischen aromatischen Kohlenwasserstoffe)
[Wikipedia]

[39] Szaefer H, Krajka-Kuzniak V, Ignatowicz E, Adamska T, Baer-Dubowska W. 2011. Chokeberry (Aronia melanocarpa) juice modulates 7,12-dimethylbenz[a]anthracene induced hepatic but not mammary gland phase I and II enzymes in female rats. Environ Toxicol Pharmacol 31:339–46
[PubMed]

[40] Koriem KM, Soliman RE. 2014. Chlorogenic and caftaric acids in liver toxicity and oxidative stress induced by methamphetamine. J Toxicol 2014:583494.
PubMed

[41] Balansky R, Ganchev G, Iltcheva M, Kratchanova M, Denev P, Kratchanov C, Polasa K, D'Agostini F, Steele VE, De Flora S. 2012. Inhibition of lung tumor development by berry extracts in mice exposed to cigarette smoke. Int J Cancer 131:1991–7.
PubMed

[42] Balansky R, Ganchev G, Iltcheva M, Kratchanova M, Denev P, Kratchanov C, Polasa K, D'Agostini F, Steele VE, De Flora S. 2012. Inhibition of lung tumor development by berry extracts in mice exposed to cigarette smoke. Int J Cancer 131:1991–7.
PubMed

[43] Khandelwal N, Abraham SK. 2014. Intake of anthocyanidins pelargonidin and cyanidin reduces genotoxic stress in mice induced by diepoxybutane, urethane and endogenous nitrosation. Environ Toxicol Pharmacol 37:837–43.
PubMed

[44] Gasiorowski K, Szyba K, Brokos B, Kolaczynska B, Jankowiak-Wlodarczyk M, Oszmianski J. 1997. Antimutagenic activity of anthocyanins isolated from Aronia melanocarpa fruits. Cancer Lett 119:37–46.
PubMed

[45] Varela-Carver A, Parker H, Kleinert C, Rimoldi O. 2010. Adverse effects of cigarette smoke and induction of oxidative stress in cardiomyocytes and vascular endothelium. Curr Pharm Des 16:2551–8.
PubMed

[46] Braun KF , Ehnert S. , Freude T. , Egaña J. , Schenck TL , Buchholz A. , Schmitt A. , Siebenlist S. , Schyschka L. , Neumaier M. , Stöckle U. , Nussler AK . 2011 . Quercetin Protects Primary Human Osteoblasts Exposed to Cigarette Smoke through Activation of the Antioxidative Enzymes HO-1 and SOD-1. Sci Welt J 11 : 2348 - 57 .
Web of Science®

[47] Antiarrhythmikum
Gelbe Liste

[48] Valcheva-Kuzmanova S, Stavreva G, Dancheva V, Terziev L, Atanasova M, Stovanova A, Dimitrova A, Shopova V. 2014. Effect of Aronia melanocarpa fruit juice on amiodarone-induced pneumotoxicity in rats. Pharmacogn Mag 10:132–40.
PubMed

[49] Antiphlogistika/Antirheumatika
Gelbe Liste

[50] Valcheva-Kuzmanova S, Marazova K, Krasnaliev I, Galunska B, Borisova P, Belcheva A. 2005. Effect of Aronia melanocarpa fruit juice on indomethacin-induced gastric mucosal damage and oxidative stress in rats. Exp Toxicol Pathol 56:385–92.
PubMed

[51] Zytostatika
kinderkrebsinfo

[52] Valcheva-Kuzmanova S, Beronova AB, Momekor GT. 2013a. Protective effect of Aronia melanocarpa fruit juice in a model of cisplatin-induced cytotoxicity in vitro. Folia Medica (Plovdiv) 55:76–9.
researchgate

[53] Cyclophosphamid
DocCheck 

[54] Behandlung der Schizophrenie
Gelbe Liste

[55] Niedworok J , Andryskowski G , Blaszczyk J , kopff M . 1995 . [Antyoksydacyjne dzialanie barwnika antocyjaninowego z aronii czarnoowocowej] . Wiad Ziel 37 : 21 - 3 .
[
ZYWNOSC]

[56] Dietrich-Muszalska A, Kopka J, Kontek B. 2014. Polyphenols from Aronia melanocarpa reduce the plasma lipid peroxidation induced by ziprasidone. Schizophr Res Treat 2014:602390.
hindawi

[57] Gyamlani, G.G., Parikh, C.R. Acetaminophen toxicity: suicidal vs accidental. Crit Care 6, 155 (2002). https://doi.org/10.1186/cc1475
 Springer

[58] El-Shafey MM, Abd-Allah GM, Mohamadin AM, Harisa GI, Mariee AD. 2015. Quercetin protects against acetaminophen-induced hepatorenal toxicity by reducing reactive oxygen and nitrogen species. Pathophysiology 22:49–55.
PubMed

[59] Rifampicin Antibiotikum, Tuberkulose, Lepra, Meningokokken-Meningitis
gelbe-liste

[60] Isoniazid Chemotherapie,
gelbe-liste

[61] Qader GI, Aziz RS, Ahmed ZA, Abdullah ZF, Hussain SA. 2014. Protective effects of quercetin against isoniazid and rifampicin induced hepatotoxicity in rats. Am J Pharmacol Sci 2:56–60.
researchgate

[62] Etoposid Zytostatikum, Tumoren, Lymphomen und Leukämien
gelbe-liste

[63]Papiez MA, Krzysciak W. 2014. The antioxidant quercetin protects HL-60 cells with high myeloperoxidase activity against pro-oxidative and apoptotic effects of etoposide. Acta Biochem Pol 61:795–9.
Web of Science®

[64]  Yong-Deok Jeon, Sa-Haeng Kang, Kwang-Hyun Moon, Jeong-Ho Lee, Dae-Geun Kim, Wook Kim, Jong-Sung Kim, Byung-Yong Ahn, and Jong-Sik Jin. The Effect of Aronia Berry on Type 1 Diabetes In Vivo and In Vitro. Journal of Medicinal Food. Mar 2018.244-253.
[
Mary Ann Liebert, Inc. Publishers]

[65] Simeonov SB, Botushanov NP, Karahanian EB, Pavlova MB, Husianitis HK, Troev DM. Effects of Aronia melanocarpa juice as part of the dietary regimen in patients with diabetes mellitus. Folia Med (Plovdiv). 2002;44(3):20-23.
[
PubMed]

[66] Qin B, Anderson RA. 2012. An extract of chokeberry attenuates weight gain and modulates insulin, adipogenic and inflammatory signalling pathways in epididymal adipose tissue of rats fed a fructose-rich diet. Brit J Nutr 108:581–7.
PubMed

[67] Broncel M., Kozirog M., Duchnowicz P., Koter-Michalak M., Sikora J., Chojnowska-Jezierska J. Aronia melanocarpa extract reduces blood pressure, serum endothelin, lipid, and oxidative stress marker levels in patients with metabolic syndrome. Med. Sci. Monit. 2010;16:28–34.
[
PubMed]

[68] Jurgonski A , Juskiewicz J , Zdunczyk Z . 2008 . Ingestion of black chokeberry fruit extract leads to intestinal and systemic changes in a rat model of prediabetes and hyperlipidemiaPlant Food Hum Nutr 63 : 176 - 82 .
PubMed

[69] Luzak B, Golanski J, Rozalski M, Krajewska U, Olas B, Watala C. 2010. Extract from Aronia melanocarpa fruits potentiates the inhibition of platelet aggregation in the presence of endothelial cells. Archiv Med Sci 6:141–4.
PubMed

[70] Malinowska J, Oleszek W, Stochmal A, Olas B. 2013. The polyphenol-rich extracts from black chokeberry and grape seeds impair changes in the platelet adhesion and aggregation induced by a model of hyperhomocystenemia. Eur J Nutr 52:1049–57.
PubMed

[71] Olas B, Wachowicz B, Nowak P, Kedzierska M, Tomczak A, Stochmal A, Oleszek W, Jeziorski A, Piekarski J. 2008a. Studies on antioxidant properties of polyphenol-rich extract from berries of Aronia melanocarpa in blood platelets. J Physiol Pharmacol 59:823–35.
PubMed

[72] Naruszewicz M, Laniewska I, Millo B, Dluzniewska M. 2007. Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infarction (MI). Atheroclerosis 194:e179–84.
PubMed

[73] Park, JM, Park JB. 2011. The preventive and therapeutic effects of Aronox extract on metabolic abnormality and hypertension. J Korean Soc Hyper 17:95–102.
Crossref

[74] Skoczynska A, Jedrychowska I, Poreba R, Affelska-Jercha A, Turczyn B, Wojakowska A, Andrzejak R. 2007. Influence of chokeberry juice on arterial blood pressure and lipid parameters in men with mild hypercholesterolemia. Pharmacol Rep 59:177–82.
Web of Science®

[75] Daskalova E, Delchev S, Peeva Y, Vladimirova-Kitova L, Kratchanova M, Kratchanov C, Denev P. 2015. Antiatherogenic and cardioprotective effects of black chokeberry (Aronia melanocarpa) juice in aging rats. Evid Based Complement Alternat Med 2015:717439.
PubMed

[76] Zapolska-Downar D, Bryk D, Malecki M, Hajdukiewicz K, Sitkiewicz D. 2012. Aronia melanocarpa fruit extract exhibits anti-inflammatory activity in human aortic endothelial cells. Eur J Nutr 51:563–72.
PubMed

[77] Bell DA, Gochenaur K. 2006. Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts. J Appl Physiol 100:1164–70.
PubMed

[78] Naruszewicz M, Laniewska I, Millo B, Dluzniewska M. 2007. Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infarction (MI). Atheroclerosis 194:e179–84.
PubMed

[79] Kowalczyk E, Fijalkowski P, Kura M, Krzesinski P, Blaszczyk J, Kowalski J, Smigielski J, Rutkowski M, Kopff M. 2005. The influence of anthocyanins from Aronia melanocarpa on selected parameters of oxidative stress and microelements contents in men with hypercholesterolemia. Pol Merkur Lek 19:651–3.
PubMed

[80] Broncel M, Koziróg-Kolacinska M, Andryskowski G, Duchnowicz P, Koter-Michalak M, Owczarczyk A, Chojnowska-Jezierska J. 2007. Effect of anthocyanins from Aronia melanocarpa on blood pressure, concentration of endothelin-1 and lipids in patients with metabolic syndrome. Pol Merkur Lek 23:116–9.
PubMed

[81] Sikora J, Broncel M, Markowicz M, Chalubinski M, Wojdan K, Mikiciuk-Olasik E. 2012. Short-term supplementation with Aronia melanocarpa extract improves platelet aggregation, clotting, and fibrinolysis in patients with metabolic syndrome. Eur J Nutr 51:549–56.
PubMed

[82] Zhao C, Giusti MM, Malik M, Moyer MP, Magnuson BA. 2004. Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth. J Agric Food Chem 52:6122–8.
PubMed

[83] Thani NAA, Keshavarz S, Lwaleed BA, Cooper AJ, Roopnai HK. 2014. Cytotoxicity of gemcitabine enhanced by polyphenolics from Aronia melanocarpa in pancreatic cancer cell line AsPC-1. J Clin Pathol 67:949–54.
 PubMed

[84] Rugina D, Sçonta Z, Leopold L, Pintea A, Bunea A, Socaciu S. 2012. Antioxidant activities of chokeberry extracts and the cytotoxic action of their anthocyanin fraction on HeLa human cervical tumor cells. J Med Food 15:700–6.
PubMed

[85] Kedzierska M, Glowacki R, Czernek U, Szydlowska-Pazera K, Potemski P, Piekarski J, Jeziorski A, Olas B. 2013a. Changes in plasma thiol levels induced by different phases of treatment in breast cancer; the role of commercial extract from black chokeberry. Mol Cell Biochem 372:47–55.
PubMed

[86] Thani NAA, Keshavarz S, Lwaleed BA, Cooper AJ, Roopnai HK. 2014. Cytotoxicity of gemcitabine enhanced by polyphenolics from Aronia melanocarpa in pancreatic cancer cell line AsPC-1. J Clin Pathol 67:949–54.
PubMed

[87] Bermúdez-Soto MJ, Larrosa M, Garcia-Cantalejo JM, Espín JC, Tomás-Barberan FA, García-Conesa MT. 2007b. Up-regulation of tumor suppressor carcinoembryonic antigen-related cell colon cancer Caco-2 cells following repetitive exposure to dietary levels of a polyphenol-rich chokeberry juice. J Nutr Biochem 18:259–71.
PubMed

[88]Malik M, Zhao C, Schoene N, Guisti M, Moyer MP, Magnuson BA. 2003. Anthocyanin-rich extract from Aronia melanocarpa induces a cell cycle block in colon cancer but not normal colonic cells. Nutr Cancer 46:186–96.
PubMed

[89] Zhao C, Giusti MM, Malik M, Moyer MP, Magnuson BA. 2004. Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth. J Agric Food Chem 52:6122–8.
PubMed

[90] Bermúdez-Soto MJ, Larrosa M, Garcia-Cantalejo JM, Espín JC, Tomás-Barberan FA, García-Conesa MT. 2007a. Transcriptional changes in human Caco-2 colon cancer cells following exposure to a recurrent non-toxic dose of polyphenol-rich chokeberry juice. Genes Nutr 2:111–3.
PubMed

[91] Kedzierska M, Glowacki R, Czernek U, Szydlowska-Pazera K, Potemski P, Piekarski J, Jeziorski A, Olas B. 2013a. Changes in plasma thiol levels induced by different phases of treatment in breast cancer; the role of commercial extract from black chokeberry. Mol Cell Biochem 372:47–55.
PubMed

[92] Kedzierska M , Olas B , Wachowicz B , Glowacki R , Bald E , Czernek U , Szydlowska-Pazera K , Potemski K , Piekarski J , Jeziorski A . 2012 . Auswirkungen des kommerziellen Aronia-Extrakts auf oxidativen Stress in Blutplättchen, die nach der Operation und verschiedenen Phasen der Chemotherapie von Brustkrebspatientinnen isoliert wurden . Fitoterapia 83 : 310 - 7 .
PubMed

[93] Olas B, Kedzierska M, Wachowicz B, Stochmal A, Oleszek W, Jeziorski A. 2010. Effect of aronia on thiol levels in plasma of breast cancer patients. Cent Eur J Biol 5:38–46.
Web of Science®

[94] Balansky R, Ganchev G, Iltcheva M, Kratchanova M, Denev P, Kratchanov C, Polasa K, D'Agostini F, Steele VE, De Flora S. 2012. Inhibition of lung tumor development by berry extracts in mice exposed to cigarette smoke. Int J Cancer 131:1991–7.
PubMed

[95] Rugina D, Sçonta Z, Leopold L, Pintea A, Bunea A, Socaciu S. 2012. Antioxidant activities of chokeberry extracts and the cytotoxic action of their anthocyanin fraction on HeLa human cervical tumor cells. J Med Food 15:700–6.
PubMed

[96] Häufigste bösartige Hirntumor bei Erwachsenen

[97] Abdullah Thani NA, Sallis B, Nuttall R, Schubert FR, Ahsan M, Davies D, Purewal S, Cooper A, Rooprai HK. 2012. Induction of apoptosis and reduction of MMP gene expression in the U373 cell line by polyphenolics in Aronia melanocarpa and by curcumin. Oncol Rep 28:1435–42.
PubMed

[98] Skupien K, Kostrzewa-Nowak D, Oszmianski J, Tarasik J. 2008. In vitro antileukaemic activity of extracts from chokeberry (Aronia melanocarpa [Michx] Elliot) and mulberry (Morus alba L.) leaves against sensitive and multidrug resistant HL60 cells. Phytother Res 22:689–94.
PubMed

[99] Sharif T, Alhosin M, Auger C, Minker C, Kim JH, Etienne-Selloum N, Bories P, Gronemeyer H, Lobstein A, Bronner C, Fuhrmann G, Schini-Kerth VB. 2012. Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells. PLoS One 7:e32526.
PubMed

[100] Wang Y, Zhao L, Wang D, Huo Y, Ji B. 2015. Anthocyanin-rich extracts from blackberry, wild blueberry, strawberry, and chokeberry: antioxidant activity and inhibitory effect on oleic acid-induced hepatic steatosis in vitro. J Food Sci Agric DOI:10.1002/jsfa.7370.
Wiley Online Library

[101]Park H, Liu Y, Kim HS, Shin JH. 2016. Chokeberry attenuates the expression of genes related to de novo lipogenesis in the hepatocytes of mice with nonalcoholic fatty liver disease. Nutr Res, 36:57–64.
PubMed

[102] Nagaya T, Tanaka N, Kimura T, Kitabatake H, Fujimori N, Komatsu M, Horiuchi A, Yamaura T, UmemuraT, Sano K, Gonzalez FJ, Aoyama T, Tanaka E. 2015. Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy. BBA Clinical 3:168–74.
PubMed

[103] Wróblewska M, Juskiewicz J, Frejnagel S, Oszmianski J, Zdunczyk Z. 2008. Physiological influence of chokeberry phenolics in model diet. Acta Aliment 37:221–32.
CAS

[104] Valcheva-Kuzmanova S, Marazova K, Krasnaliev I, Galunska B, Borisova P, Belcheva A. 2005. Effect of Aronia melanocarpa fruit juice on indomethacin-induced gastric mucosal damage and oxidative stress in rats. Exp Toxicol Pathol 56:385–92.
PubMed

[105] Savikin K, Menkovic N, Zdunic G, Pljevljakušic D, Spasic S, Kardum M, Konic-Ristic A. 2014. Dietary supplementation with polyphenol-rich chokeberry juice improves skin morphology in cellulite. J Med Food 17:582–7.
PubMed

[106] Shin JH, Jung JH. 2016. Reduction of adipogenesis by chokeberry (Aronia melanocarpa) extract in 3T3-L1 preadipocytes. J Food Nutr Res 4:210–5.
sciepub

[107] Aristizabal JC, Barona J, Gonzalez-Zapata I, Deossa GC, Estrada A. 2016. Fatty acid content of plasma triglycerides may contribute to the heterogeneity in the relationship between abdominal obesity and the metabolic syndrome. Metab Syndr Relat Disord:
PubMed

[108] Kefer JC, Agarwal A, Sabanegh E. 2009. Role of antioxidants in the treatment of male infertility. Int J Urol 16:449–57.
PubMed

[109] Pawlowicz P, Stachowiak G, Bielak A, Wilczynski J. 2001. [Administration of natural anthocyanins derived from chokeberry (Aronia melanocarpa) extract in the treatment of oligospermia in males with enhanced autoantibodies to oxidized low density lipoproteins (oLAB). The impact on fructose levels]. Ginekol Pol 72:983–8. (Article in Polish)
PubMed

[110] Kim, N.-H.; Jegal, J.; Kim, Y.N.; Heo, J.-D.; Rho, J.-R.; Yang, M.H.; Jeong, E.J. The Effects of Aronia melanocarpa Extract on Testosterone-Induced Benign Prostatic Hyperplasia in Rats, and Quantitative Analysis of Major Constituents Depending on Extract Conditions. Nutrients 2020, 12, 1575.
mdpi

[111] Eftimov MT, Valcheva-Kuzmanova SV. 2014a. Antidepressant-like effect of Aronia melanocarpa fruit juice applied subchronically to rats. Seventh National Congress of Pharmacology; Pleven, Bulgaria; 17–19 October 2014. J Biomed Clin Res 7(Suppl 1):58.
Open Journal Systems

[112] Eftimov MT, Valcheva-Kuzmanova SV. 2014b. Anxiolytic-like effect of Aronia melanocarpa fruit juice applied subchronically to rats. Seventh National Congress of Pharmacology; Pleven, Bulgaria; 17–19 October 2014. J Biomed Clin Res 7(Suppl 1):59..
Medical University of Varna

[113] Pawlowicz P, Wilczynski J, Stachowiak G, Hincz P. 2000. [Administration of natural anthocyanins derived from chokeberry retardation of idiopathic and preeclamptic origin. Influence on metabolism of plasma oxidized lipoproteins: the role of autoantibodies to oxidized low density lipoproteins]. Ginekol Pol 71:848–53. (Article in Polish)
PubMed

[114] Черноплодная рябина, или арония Мичурина, – действительно уникальное растение. Хотя она относится к тому же семейству, что и красная рябина, близкими родственниками они не являются.
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